|Title||Giglio Nero Primo|
|Famiglia||Giglio Nero Famiglia|
|Manga Debut||Chapter 387|
Sepira wore the Giglio Nero clothing that her descendants wore as well, which had a big, white, mushroom-shaped hat with half of the emblem of the Giglio Nero on it. It also had a large black bar at the sides, with two orange stripes flanking it. She wore a stiff jacket that had the Giglio Nero emblem emblazoned on the right side of the collar. Additionally, she also had the Giglio Nero emblem tattooed onto her right cheek, like her descendants, though theirs were tattooed on the left. Her hair, from what little can be seen of it, was short and dark.
Not much is known about her but it can be assumed that she liked humans more than Kawahira does, considering that she wanted to coexist with humans and entrusted Giotto, a human, with the Vongola Rings.
Sepira was a member of a species that lived on Earth even before the humans, and was one of their last members, along with Kawahira. Unable to support the Tri-ni-set on their own, they split it up into the Arcobaleno Pacifiers, the Mare Rings, and the Vongola Rings. She was the founder of the Giglio Nero Famiglia. While she took the set of Mare Rings to be passed down within her Famiglia, she entrusted the set of Vongola Rings to Giotto, the boss of Vongola Famiglia. At one point during her time, she and Kawahira had conflicted opinions as she wanted to coexist with humans while Kawahira didn't and thus, she parted ways with him.
- Mare Rings: Sepira obtained the set of Mare Rings from the original Tri-ni-set before she founded the Giglio Nero Famiglia and passed them down through the generations of Giglio Nero Bosses.