It may contain SPOILERS.
Continue reading at your own risk.
Nana is a petite and thin woman, she has short brown hair and brown eyes in a bob style. She and her son are similar in appearances.
Nana is a kind and compassionate woman, she is very welcoming to many of her sons friends and doesn't have any problem inviting new people into her home, she is always feeding the people who live in her house and does not think they are strange. In spite of her caring nature, Nana has fairly little belief in her son succeeding in life. She does not expect him to get into a good college, has outbursts that he's a loser, and even thanks Kyoko on her knees when she believes that she's Tsuna's girlfriend. Nana is unaware that her husband and son are involved in the mafia, a secret that Iemitsu deliberatly keeps from her, and she is completely kept away from the mafia. She has only caught two glimpses of the mafia, however, she faints and believes they are dreams on both occasions. At times she's aware that her husband and son are hiding something from her, which frustrates her.
Nothing is known about her past except the fact that she worked as a waitress before marrying Iemitsu.
Nana first appeared finding out about Reborn's letter of being a home tutor. She's often being seen cooking and running errands for the family. Reborn, Bianchi, Lambo, I-Pin, Fuuta de la Stella, and Dino call her Mama.
Nana is oblivious about Tsuna and his friends' fight with the Varia and is seen to be very happy after her husband, Iemitsu comes home. She stays at the hospital where Lambo is charged after the Lightning Ring Battle, worrying over Lambo's condition.
In the Future Arc, she was revealed to be on vacation with her husband in Italy when the Millefiore Famiglia attacked the Vongola Headquarters; her condition in the Future was unknown after that.
Nana is first seen reprimanding Tsuna for stating to his father Iemitsu that whenever he came home, things got weird. Nana then goes on to meet with Iemitsu's CEDEF subordinates, whom he introduces as his "fellow workers" when digging for oil, also happily agreeing to let them stay at their house. When Byakuran arrives and flies up to Tsuna's balcony on the second floor, Nana remains oblivious and wonders if it was a magic trick. When the Vindice attacked team Collonello at Tsuna's house, Nana came out telling Iemitsu that he would disturb the neighbors with the noise he was making. The Vindice then attacked her. She eventually makes a full recovery and her memories are erased, making her think the attack was a dream.
- In the Reborn! Fandom, her number is 77.
- Nana means seven in the Japanese language.
- When Spanner was the guest at the Haru Haru's Interview: Dangerous, he was looking for a Yamato Nadeshiko (a woman with a gentle heart). Reborn said that there's only one woman he knows that fits said description and it was Nana Sawada, even though Haru had been hoping to be the one.
- She had long hair when Tsuna was still young. Her previous hairstyle was similar to future Kyoko Sasagawa's.
- Lambo is only able to activate his Cambio Forma when he misses Nana, evidencing Lambo's devotion to Nana.
- She is referred to as Mama by Reborn, Fuuta, Dino, I-Pin, Bianchi, Gokudera, and Lambo.
- Nana and Iemitsu are ranked first as a "loving married couple" by Fuuta.
- Fuuta's ranking shows that Nana's omelettes are first-rate.